A High Factor II/Factor X Functional Ratio Is Not a Useful Predictor of the FII G20210A Gene Mutation in Thromboembolic Patients Undergoing Oral Anticoagulant Treatment
نویسندگان
چکیده
منابع مشابه
A high factor II/Factor X functional ratio is not a useful predictor of the FII G20210A gene mutation in thromboembolic patients undergoing oral anticoagulant treatment.
To the Editor: A G3A transition at nucleotide 20210 in the prothrombin gene has recently been associated with venous thromboembolism in a Dutch population (1 ). The prevalence of this genetic variation in Western countries is 5–15% among thrombotic patients and 1–5% in healthy controls (2–5). The main pathogenic mechanism appears to be the increase of plasma prothrombin (FII) because many carri...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2000
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/46.6.886